氢氧化钠 → HCID 69795151，化合物

HRID 2181663笔记

反应方程式

HRID 2181663 反应方程式
[NH2:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([O:15]C)=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3].[OH-].[Na+]>CO.O>[NH2:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3]

参与物

5

反应物 2

HCID 14798氢氧化钠HCID 22481693HCID 22481693，化合物

产物 1

HCID 69795151HCID 69795151，化合物收率 93%

试剂、催化剂与溶剂 2

HCID 887Methanol溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

反应条件

温度
50 °C

实验过程

Methyl 2-(aminocarbonyl)-1-benzofuran-6-carboxylate(164 mg, 0.75 mmol) is dissolved in MeOH (5 mL) and water (1 mL), treated drop-wise with 2N NaOH (450 μL, 0.9 mmol) and monitored by TLC. The volatiles are removed in vacuo, and the resulting tan solid is dissolved in water (5 mL) and acidified to pH 3 with concentrated HCl. The resulting solid is collected via filtration and dried in a vacuum oven with heat 50° C. to afford 142 mg (93%) of 2-(aminocarbonyl)-1-benzofuran-6-carboxylic acid as an orange solid. HRMS (EI) calcd for C10H7NO4: 205.0375, found 205.0378 (M)+.

后处理

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe resulting tan solid is dissolved in water (5 mL)
  3. filtrationThe resulting solid is collected via filtration
  4. customdried in a vacuum oven

来源与证据

ORD记录
ord-7aade1f6d7e34b47b9d9c483c4a4994f
来源数据集
uspto-grants-2005_05
专利号
US06894042B2

反应笔记

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