乙酸铵 → 1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181908笔记

反应方程式

HRID 2181908 反应方程式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

参与物

5

反应物 3

HCID 517165乙酸铵HCID 5003444氰基硼氢化钠HCID 224823721-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

产物 1

HCID 224823821-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

The title compound was prepared from 1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (720 mg, 2.9 mmol), anhydrous methanol (10 mL), ammonium acetate (4.44 g, 58 mmol), and sodium cyanoborohydride (362 g, 5.8 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 114, step c;

后处理

  1. customThe crude amine was immediately used without further purification in Example 114, step c

来源与证据

ORD记录
ord-aedbfb1c67b5452db02693817d12d88e
来源数据集
uspto-grants-2005_05
专利号
US06894061B2

反应笔记

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