氢溴酸 → 2-溴-1-[4-羟基-3-(羟甲基)苯基]乙-1-酮
反应方程式
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:14])[CH2:12][Br:13])=[CH:7][C:6]=1[CH2:15][O:16]C(=O)C)(=O)C.Br.O>CO>[Br:13][CH2:12][C:11]([C:8]1[CH:9]=[CH:10][C:5]([OH:4])=[C:6]([CH2:15][OH:16])[CH:7]=1)=[O:14]参与物
5
实验过程
2-Acetoxymethyl-4-bromoacetylphenyl acetate (18.6 g) was dissolved in methanol (90 ml), and 47% hydrobromic acid (100 ml) was added to the solution under ice-cooling with stirring. After reaction for 16 hours at room temperature, water was added to the reaction mixture under ice-cooling with stirring, and the precipitates were collected by filtration and washed with water and hexane to give 2-bromo-4'-hydroxy-3'-hydroxymethylacetophenone (9.54 g) having a melting point of 117-119° C.
后处理
- temperaturecooling
- customAfter reaction for 16 hours at room temperature
- temperaturecooling
- stirringwith stirring
- filtrationthe precipitates were collected by filtration
- washwashed with water and hexane
来源与证据
- ORD记录
- ord-cfb39df89f724af9b05e67f90861301d
- 来源数据集
- uspto-grants-2000_10
- 专利号
- US06136852
反应笔记
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