Iodoethane → 邻乙氧基萘甲醛

HRID 544337笔记

反应方程式

HRID 544337 反应方程式
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]=[O:13].I[CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:15]([O:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]=[O:13])[CH3:16]

参与物

5

反应物 3

HCID 6340IodoethaneHCID 11430碳酸钾HCID 128192-羟基-1-萘甲醛

产物 1

HCID 88099邻乙氧基萘甲醛

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

实验过程

2-Hydroxy-1-naphthaldehyde (10 g., 0.058 mole) was combined with acetone (120 ml.), iodoethane (9.9 g., 0.063 mole) and anhydrous potassium carbonate (8.0 g., 0.058 mole) and the mixture heated to reflux for 48 hours. The reaction mixture was cooled to room temperature, filtered and filtrate evaporated to solids (9.0 g.) Recrystallization from isopropyl ether afforded purified 2-ethoxy-1-naphthaldehyde in two crops (4 5 g. and 0.5 g., m.p. 106°-109° C.).

后处理

  1. temperaturethe mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationfiltered
  4. customfiltrate evaporated to solids (9.0 g.) Recrystallization from isopropyl ether
  5. customafforded
  6. custompurified 2-ethoxy-1-naphthaldehyde in two crops (4 5 g. and 0.5 g., m.p. 106°-109° C.)

来源与证据

ORD记录
ord-690cd4173f8f47649acec3860e20b21f
来源数据集
uspto-grants-1984_05
专利号
US04448971

反应笔记

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