1-(2-ethoxycarbonylpropanoyl)-L-proline → 1-(2-carboxypropanoyl)-L-proline
反应方程式
C([O:3][C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])=[O:5])C>[OH-].[Na+].CO>[C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])([OH:5])=[O:3]参与物
4
实验过程
1-(2-Ethoxycarbonylpropanoyl)-L-proline (4.1 g.) is dissolved in a mixture of N sodium hydroxide (51 ml.) and methanol (51 ml.). The solution is kept at room temperature for 6 hours and then concentrated to half volume in vacuo. Ion exchange resin (Dowex 50) (50 ml.) is added and the suspension applied to a column of 150 ml. of the same resin. The fractions containing the desired material (carboxyl reagent positive) are pooled and freeze dried to obtain to obtain 1-(2-carboxypropanoyl)-L-proline, yield 1.5 g.
后处理
- concentrationconcentrated to half volume in vacuo
- additionIon exchange resin (Dowex 50) (50 ml.) is added
- additionThe fractions containing the desired material (carboxyl reagent positive)
- customfreeze dried
- customto obtain
来源与证据
- ORD记录
- ord-8448bd16a15c41d0a037a2d38a5457f8
- 来源数据集
- uspto-grants-1978_12
- 专利号
- US04128653
反应笔记
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