盐酸 → HCID 178518410，化合物
反应方程式
[NH:1]([C:5]1[CH:9]=[CH:8][O:7][C:6]=1[C:10]([O:12]CC)=O)[C:2]([NH2:4])=[O:3].[OH-].[Na+].Cl>CO>[N:1]1[C:5]2[CH:9]=[CH:8][O:7][C:6]=2[C:10]([OH:12])=[N:4][C:2]=1[OH:3]参与物
5
实验过程
Ethyl 3-ureidofuran-2-carboxylate 35 (120 mg, 1.0 eq) was suspended in methanol (6 ml) and treated with 1.5 M NaOH (1.5 ml). Reaction mixture was heated to reflux for 90 minutes. Reaction mixture was allowed to cool down to room temperature, and was acidified with 6N HCl up to pH 3. Mixture was concentrated. Methanol was added to residue and solid was filtered and dried at 95° C. under high vacuum for 24 h to yield furo[3,2-d]pyrimidine-2,4-diol 36 (90 mg, 91%) which was used in the next reaction without further purification.
后处理
- customReaction mixture
- temperaturewas heated
- temperatureto reflux for 90 minutes
- customReaction mixture
- concentrationMixture was concentrated
- additionMethanol was added to residue and solid
- filtrationwas filtered
- customdried at 95° C. under high vacuum for 24 h
来源与证据
- ORD记录
- ord-2d0cf41953e84f3c9f47e27529180557
- 来源数据集
- uspto-grants-2015_03
- 专利号
- US08993563B2
反应笔记
加载中…