1-Desoxy-1-(methylamino)-D-glucitol-2-[2-methyl-3-(perfluormethyl)anilino]nicotinat
Flunixin Meglumine
Grundinformationen
- CAS
42461-84-7- Standard-SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F- InChIKey
MGCCHNLNRBULBU-WZTVWXICSA-N- Summenformel
- C21H28F3N3O7
- Durchschnittliche Molmasse
- 491,5 g/mol
Überblick
Flunixin meglumine is an organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It contains a flunixin(1-).
Namen und Bezeichner
- Bevorzugter Name
- Flunixin Meglumine
- IUPAC
- (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
- Lokaler Name
- 1-Desoxy-1-(methylamino)-D-glucitol-2-[2-methyl-3-(perfluormethyl)anilino]nicotinat
- Englischer Name
- Flunixin Meglumin
- Summenformel
- C14H11F3N2O2.C7H17NO5
- Molmasse
- 491.46
Namen und Synonyme
FLUNIXIN MEGLUMINE42461-84-7BanamineFlumeglumineSch 14714 meglumineFlunixin-SFlunixin N-methylglucanineSch-14714 meglumine8Y3JK0JW3UFlunixin meglumine saltFlunazineNSC-759583
Weitere Namen anzeigen
flunixin megluminFlunixin Meglunine1-deoxy-1-(methylamino)-d-glucito2-((2-methyl-3-(trifluoromethyl)phenyl)amFinadyneEquileveNIH 10250fluixi egluieIliuM Flunixil
CHEBI:761442-((2-Methyl-3-(trifluoromethyl)-phenyl)amino)-3-pyridinecarboxylic acid with meglumine compoundedDTXCID9025584FlunineVetaMegBanamine PasteFlunazine-SVetameg S
Datenbank-Bezeichner
- CAS
42461-84-7
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 175 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 13
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 34
- Formalladung
- 0
- Komplexität
- 510
Experimentelle und physikochemische Eigenschaften
DrugsDEA NFLIS-Drug Category -> Analgesics
Animal DrugsActive Ingredients (Flunixin Meglumine) -> FDA Greenbook
Physikochemische Eigenschaften
- Schmelzpunkt
- 136.6 · 136.6-137.4 °C
- storage temp.
- room temp
- Löslichkeit
- 2 O: · H2O: freely soluble
- Aggregatzustand
- solid
- Farbe
- off-white
- Wasserlöslichkeit
- soluble
- InChIKey
- MGCCHNLNRBULBU-WZTVWXICSA-N
- SMILES
- CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 0.5% (1 of 215) of reports.
Danger
H301 (79.5%): Toxic if swallowed [Danger Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 215 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationFlunixin meglumine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - D-Glucitol, 1-deoxy-1-(methylamino)-, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (79.5%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1 / PGI
- hs_code
- 29339900
- RTECS-Nr.
- LZ4367000
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Drugs that are used to reduce body temperature in fever.
Verwendung und Herstellung
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Anwendungen
VerwendenFlunixin meglumine has been used as a nonsteroidal anti-inflammatory drug standard in electrospray ionization mass spectrometry (LC-ESI/MS).
Ergänzende Hinweise
DefinitionChEBI: An organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic propert es; used in veterinary medicine for treatment of horses, cattle and pigs.
Zugehörige Reaktionen
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