Citric Acid → Florfenicol Flunixin

HRID 1666773

Reaktionsgleichung

Reaktionsgleichung von HRID 1666773
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)C(O)C.C1OCOC1CO.[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:67])([F:66])[F:65].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>CC(N(C)C)=O.CN1C(=O)CCC1>[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:66])([F:65])[F:67]

Komponenten

8

Edukt 5

HCID 311Citric AcidHCID 1030Propylene GlycolHCID 216181,3-Dioxolane-4-methanol2×HCID 39212Flunixin MeglumineHCID 114811Florfenicol

Produkt 1

HCID 86602307Florfenicol Flunixin

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 13387N-methyl-2-pyrrolidoneLösungsmittelHCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

The NMP or dimethylacetamide, citric acid, propylene glycol, and approximately 90% of the PEG 300 or glycerol formal required for each formulation were charged to the compounding vessel and mixed well. The florfenicol and flunixin meglumine were added with mixing until all solids were dissolved. The volume was adjusted with the remaining PEG 300 or glycerol formal.

Aufarbeitung

  1. additionwere charged to the compounding vessel
  2. additionmixed well
  3. additionwith mixing until all solids
  4. dissolutionwere dissolved

Quellen und Nachweise

ORD-Eintrag
ord-f33629d272154f038dc051a2ce161aaf
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044102B2

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