Piperazinone, 3-(2-thienyl)- (9CI)
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Grundinformationen
- CAS
85606-97-9- Standard-SMILES
O=C1NCCNC1c1cccs1- InChIKey
BBACKDMGYMXYLE-UHFFFAOYSA-N- Summenformel
- C8H10N2OS
- Durchschnittliche Molmasse
- 182,24 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Piperazinone, 3-(2-thienyl)- (9CI)
- Englischer Name
- Piperazinone, 3-(2-thienyl)- (9CI)
- Summenformel
- C8H10N2OS
- Molmasse
- 182.24
Namen und Synonyme
Tenilsetam3-(2-thienyl)- (9CI)Tenilsetam/PiperazinoneTenilsetam, 10 mM in DMSO3-(2-Thienyl)-2-piperazinone3-(2-Thienyl)piperazin-2-one2-Piperazinone, 3-(2-thienyl)-Piperazinone, 3-(2-thienyl)- (9CI)Tenilsetam - PAS 997 | CAS 997 | HR 029Piperazinone, 3-(2-thienyl)- (9CI) USP/EP/BP
Datenbank-Bezeichner
- CAS
85606-97-9、86696-86-8- PubChem CID
- 65649
- ChEMBL
CHEMBL2104853- ChEBI
CHEBI:232422- UNII
- O4Q7XM74N6
- EC Number
- 978-346-5
- Nikkaji
- J330.845F
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 1.225 · 1.225
- InChI
- InChI=1S/C8H10N2OS/c11-8-7(9-3-4-10-8)6-2-1-5-12-6/h1-2,5,7,9H,3-4H2,(H,10,11)
- InChIKey
- BBACKDMGYMXYLE-UHFFFAOYSA-N
- SMILES
- N1CCNC(C2SC=CC=2)C1=O
Chemie und Industrie
Anwendungen
BeschreibungTenilsetam ((+/-)-3-(2-thienyl)-2-piperazinone; Piperazinone, 3-(2-thienyl)- (9CI)), a cognition-enhancing drug successfully used for the treatment of patients suffering from Alzheimer's disease, when included in the Maillard reaction inhibits protein crosslinking by AGEs in vitro. According to the mechanism proposed, Tenilsetam acts via covalent attachment to glycated proteins, thus blocking the reactive sites for further polymerisation reactions. A beneficial effect of Tenilsetam in Alzheimer's disease could come from the interference with AGE-derived crosslinking of amyloid plaques and a decreased inflammatory response by diminished activation of phagocytosing microglia[1].
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