Bromine → 5-Bromo-2-hydroxy-4-methyl-3-nitropyridine

HRID 1005402

Reaktionsgleichung

Reaktionsgleichung von HRID 1005402
[CH3:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[N+:9]([O-:11])=[O:10].C([O-])(=O)C.[Na+].[Br:17]Br>C(O)(=O)C.C(OCC)(=O)C>[Br:17][C:7]1[C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[C:4](=[O:8])[NH:5][CH:6]=1

Komponenten

6

Edukt 3

HCID 24408BromineHCID 3453702-Hydroxy-4-methyl-3-nitropyridineHCID 517045Sodium Acetate

Produkt 1

HCID 217065175-Bromo-2-hydroxy-4-methyl-3-nitropyridineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-methyl-3-nitro-2-pyridone (0.45 g, 2.9 mmol) in glacial acetic acid (3 mL) was added sodium acetate (0.24 g) followed by bromine (0.15 mL) dropwise. After 5.5 hours, the mixture was diluted with ethyl acetate, washed with water, dried, filtered and concentrated to give 5-bromo-4-methyl-3-nitro-2-pyridone (0.62 g, 2.6 mmol, 90%).

Aufarbeitung

  1. washwashed with water
  2. customdried
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7220faf6d534434d8c42bdc355799762
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06054470

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