Hippuric Acid → 2-Carboxymethylbenzaldehyde hippuric acid

HRID 1020010Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020010
[C:1]([CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([OH:3])=[O:2].[C:13]([OH:25])(=[O:24])[CH2:14][NH:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C([O-])(=O)C.[K+].C(OC(=O)C)(=O)C>O>[C:13]([OH:25])(=[O:24])[CH2:14][NH:15][C:16]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:17].[C:1]([CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([OH:3])=[O:2]

Komponenten

6

Edukt 4

HCID 464Hippuric AcidHCID 7918Acetic AnhydrideHCID 517044Potassium AcetateHCID 5289058Ortho-formylphenylacetic acid

Produkt 1

HCID 866643832-Carboxymethylbenzaldehyde hippuric acidAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2-Carboxymethylbenzaldehyde (4.9 g, and 30 mmoles) with hippuric acid (5.9 g, 33 moles) and potassium acetate (2.94 g, 30 mmoles) were added to acetic anhydride (14.2 mls, 150 mmoles) and the reaction heated (100° C.) for 4 hours. To the cooled reaction was added water (100 mls) and stirred overnight. The resulting solid was collected by filtration and washed with water and dried (7.6 g, 83% yield).

Aufarbeitung

  1. customTo the cooled reaction
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with water
  4. customdried (7.6 g, 83% yield)

Quellen und Nachweise

ORD-Eintrag
ord-4a4960fcc1c545198d1acb95e8f49687
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716302B2

Notizen zur Reaktion

Wird geladen…