Hydroxyamine hydrochloride → 8-[(E)-(hydroxyimino)methyl]-5-indolizinecarboxylic acid ethyl ester

To a solution of ethyl 8-formylindolizine-5-carboxylate (100 mg, 0.46 mmol) and NH2OH.HCl (48 mg, 0.69 mmol) in THF (10 mL) and H2O (3 mL) at rt was added NaOAc (75 mg, 0.92 mmol). The reaction mixture was stirred at rt for 2 h. The mixture was extracted with EA (2×20 mL). The organic layers was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was used in next step without further purification.

1. extractionThe mixture was extracted with EA (2×20 mL)
2. dry with materialThe organic layers was dried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customThe residue was used in next step without further purification

ORD-Eintrag

ord-ce59cd90490940ac835d2a8662710052

Quelldatensatz

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08546357B2