Potassium Carbonate → 4-{2-[2-(2-Methyl-pyrrolidin-1-yl)-ethyl]-benzothiazol-5-yl}-benzonitrile

HRID 10397

Reaktionsgleichung

Reaktionsgleichung von HRID 10397
C([O-])([O-])=O.[K+].[K+].[F-].[Cs+].[C:9]([C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1)#[N:10].Br[C:21]1[CH:22]=[CH:23][C:24]2[S:28][C:27]([CH2:29][CH2:30][N:31]3[CH2:35][CH2:34][CH2:33][CH:32]3[CH3:36])=[N:26][C:25]=2[CH:37]=1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C=CC=CC=2)CCCCC1>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH3:36][CH:32]1[CH2:33][CH2:34][CH2:35][N:31]1[CH2:30][CH2:29][C:27]1[S:28][C:24]2[CH:23]=[CH:22][C:21]([C:14]3[CH:15]=[CH:16][C:11]([C:9]#[N:10])=[CH:12][CH:13]=3)=[CH:37][C:25]=2[N:26]=1

Komponenten

8

Edukt 5

HCID 11430Potassium CarbonateHCID 25953Cesium fluorideHCID 27342162-(Dicyclohexylphosphino)biphenylHCID 27343264-Cyanophenylboronic acidHCID 219800005-Bromo-2-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]benzothiazole

Produkt 1

HCID 219800314-{2-[2-(2-Methyl-pyrrolidin-1-yl)-ethyl]-benzothiazol-5-yl}-benzonitrileAusbeute 31,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a reaction flask containing K2CO3 (0.326 g, 1.5 mmol), CsF (0.233 g, 1.5 mmol), and (0.19 g, 1.3 mmol) of 4-cyanophenyl boronic acid was added a solution of 5-bromo-2-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-benzothiazole (0.25 g, 0.77 mmol) in 3 mL of toluene. The resulting mixture was purged with nitrogen, and then 2-dicyclohexylphosphinobiphenyl (54 mg, 0.15 mmol) and Pd2(dba)3 (70 mg, 0.08 mmol) were added. The resulting reaction mixture was then heated at 90° C. for 2 hr. At completion, the reaction was washed with water, then diluted with with CH2Cl2, and purified by column chromatography (silica gel, 10% MeOH/CH2Cl2), to give 4-{2-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-benzothiazol-5-yl}-benzonitrile in an isolated yield of 31.5%. The hydrochloride salt of the product was formed by adding 6N HCl (2 equivalents) in isopropanol solution and then diluting with 1 mL of isopropanol, followed by removal of solvent. 1H NMR (400 MHz, Methanol d4) δ 1.47 (d, J=6.45 Hz, 3 H) 1.72 (dd, J=12.76, 8.37 Hz, 1 H) 2.29 (m, 2 H) 3.23 (m, 3 H) 3.36 (t, J=7.14 Hz, 1 H) 3.62 (m, 3 H) 3.99 (m, 1 H) 7.68 (dd, J=8.44, 1.72 Hz, 1 H) 7.77 (m, 4 H) 8.01 (d, J=8.37 Hz, 1 H) 8.17 (d, J=1.51 Hz, 1 H) [M+H]+ at m/z 348.

Aufarbeitung

  1. customThe resulting mixture was purged with nitrogen
  2. customThe resulting reaction mixture
  3. washAt completion, the reaction was washed with water
  4. additiondiluted with with CH2Cl2
  5. custompurified by column chromatography (silica gel, 10% MeOH/CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-edb4a5288d3a40f7b9ddd0afc3612493
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094790B2

Verknüpfte Notizen

Wird geladen…