Diethyl Ether → HCID 58430895, Verbindung

HRID 1040469

Reaktionsgleichung

Reaktionsgleichung von HRID 1040469
Cl.[CH:2]1([CH2:5]C(=N)OCC)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].Cl.[NH2:18][CH2:19][C:20]#[N:21].[CH3:22][CH2:23][O:24]CC>O>[CH2:23]([O:24][C:5]([CH:2]1[CH2:3][CH2:4]1)=[N:21][CH2:20][C:19]#[N:18])[CH3:22]

Komponenten

6

Edukt 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 11491918Aminoacetonitrile hydrochlorideHCID 14860732Ethyl 2-cyclopropylethanecarboximidate hydrochloride

Produkt 1

HCID 58430895HCID 58430895, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a suspension of ethyl cyclopropylacetimidate hydrochloride (6.0 g, 53 mmol) in ether (50 mL) was added anhydrous potassium carbonate (7.3 g, 53 mmol). After stirring for 5 min, a solution of aminoacetonitrile hydrochloride (4.9 g, 53 mmol) in water (40 mL) was added and the mixture stirred for additional 90 min. The reaction was diluted with water (100 mL) and extracted with ether (2×300 mL). The combined organic fractions were dried (Na2SO4), filtered, and concentrated to give N-cyanomethyl-cyclopropanecarboximidic acid ethyl ester as a liquid (4.54 g).

Aufarbeitung

  1. stirringthe mixture stirred for additional 90 min
  2. extractionextracted with ether (2×300 mL)
  3. dry with materialThe combined organic fractions were dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4068d6d00af54e1d8378c89ccb98a1f8
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552205B2

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