Estradiol → Androst-4-en-3-one, 17-hydroxy-, (17beta)-, mixt. with (17beta)-estra-1,3,5(10)-triene-3,17-diol

HRID 1052886

Reaktionsgleichung

Reaktionsgleichung von HRID 1052886
[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][C@@:22]12[C@@H:30]([OH:31])[CH2:29][CH2:28][C@H:27]1[C@@H:26]1[CH2:32][CH2:33][C:34]3[C@@:40]([CH3:41])([C@H:25]1[CH2:24][CH2:23]2)[CH2:39][CH2:38][C:36](=[O:37])[CH:35]=3>O>[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][C@@:22]12[C@@H:30]([OH:31])[CH2:29][CH2:28][C@H:27]1[C@@H:26]1[CH2:32][CH2:33][C:34]3[C@@:40]([CH3:41])([C@H:25]1[CH2:24][CH2:23]2)[CH2:39][CH2:38][C:36](=[O:37])[CH:35]=3

Komponenten

4

Edukt 2

HCID 5757EstradiolHCID 6013Testosterone3×

Produkt 1

HCID 66445Androst-4-en-3-one, 17-hydroxy-, (17beta)-, mixt. with (17beta)-estra-1,3,5(10)-triene-3,17-diol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Stock solution of estradiol and testosterone were diluted with water and mixed with Freund's incomplete adjuvant. This was mixed continuously for 1 minute and either 100 ul (E1 and E3) or 200 ul (E2 and E4) were injected subcutaneously. Estrogen or testosterone release was continuous over six days. Peak measured levels were obtained in 24 hr as shown in previous studies. Animals in the E1 and E3 groups were targeted to receive 100-300 pg/ml estrogen and groups E2 and E4 were targeted to receive 400-800 pg/ml of estrogen. Animals in T1 and T2 grouping were targeted to receive 100 pg/ml testosterone.

Aufarbeitung

  1. additionmixed with Freund's incomplete adjuvant
  2. additionThis was mixed continuously for 1 minute
  3. customwere obtained in 24 hr

Quellen und Nachweise

ORD-Eintrag
ord-d61a3460b3f343a5af2a4e0ad9858ae2
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09389237B2

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