Pyruvic Acid → 7-Chloro-3-methylquinoxalin-2(1h)-one

HRID 1055031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1055031
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.O=[C:11]([CH3:15])[C:12](O)=[O:13]>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:8][C:12](=[O:13])[C:11]([CH3:15])=[N:9]2.[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([N:8]=[C:11]([CH3:15])[C:12](=[O:13])[NH:9]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 1060Pyruvic AcidHCID 72634-Chloro-1,2-diaminobenzene

Produkt 2

HCID 2581487-Chloro-3-methylquinoxalin-2(1h)-oneAusbeute 148,1 %HCID 11636992HCID 11636992, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

4-chlorobenzene-1,2-diamine (5 g, 35.1 mmol, Eq: 1.00) was stirred in water (50 ml) at room temperature. 2-Oxopropanoic acid (3.09 g, 2.44 ml, 35.1 mmol, Eq: 1.00) in water (20 ml) was added drop wise. The dark mixture was stirred at room temperature for 30 min. The precipitate was filtered off and washed with water and dried under high vacuum to give 6-chloro-3-methyl-1H-quinoxalin-2-one with 7-chloro-3-methyl-1H-quinoxalin-2-one (5.06 g, 37.1%) as brown solid. MS: m/z=195.03 (M+H+)

Aufarbeitung

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0fca87ee4d614167b080439c3007499c
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394311B2

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