Acetic Acid → 4-Methylsulfonylacetophenone

HRID 1065

Reaktionsgleichung

Reaktionsgleichung von HRID 1065
[O-][Mn](=O)(=O)=O.[K+].[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13](SC)=[CH:12][CH:11]=1)=[O:9].[S:18]([O-:21])([O-])=[O:19].[Na+].[Na+].[C:24](O)(=O)C>O>[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([S:18]([CH3:24])(=[O:21])=[O:19])=[CH:12][CH:11]=1)=[O:9]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 24437Sodium SulfiteHCID 745011-(4-(Methylthio)phenyl)ethan-1-oneHCID 516875Potassium Permanganate

Produkt 1

HCID 825294-Methylsulfonylacetophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

Aufarbeitung

  1. customto return to room temperature
  2. waitThis is left
  3. customThe solid obtained
  4. filtrationis filtered off
  5. washwashed copiously with water
  6. customrecrystallized from 95% ethanol

Quellen und Nachweise

ORD-Eintrag
ord-6d44d87ee23a4984ad13cff1877a23a4
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723485

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