4-Methylmorpholine → HCID 11074788, Verbindung

HRID 1066026Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066026
[Si:1]([N:8]1[C:11](=[O:12])[CH2:10][C@@H:9]1[C:13](O)=[O:14])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].CN1CCOCC1.ClC(OCC(C)C)=O.[BH4-].[Na+]>C1COCC1.O.CCOC(C)=O>[Si:1]([N:8]1[C@@H:9]([CH2:13][OH:14])[CH2:10][C:11]1=[O:12])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Komponenten

8

Edukt 4

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 2733822(R)-1-(tert-Butyldimethylsilyl)-4-oxoazetidine-2-carboxylic acidHCID 4311764Sodium borohydride

Produkt 1

HCID 11074788HCID 11074788, VerbindungAusbeute 60,1 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 1-(tert-butyldimethylsilyl)-4-oxoazetidine-2(R)-carboxylic acid (15.0 g, 65.40 mmol) in THF (367 mL) at 0°, was added N-methylmorpholine (7.2 mL, 65.40 mmol) and isobutyl chloroformate (8.5 mL, 65.40 mmol). After stirring for 1.5 h at 0° a solution of NaBH4 (9.9 g, 261.61 mmol) in H2O (98 mL) was added portionwise. The reaction was stirred for 45 min, then diluted with EtOAc and quenched with aqueous HCl solution (10%) to pH 5-6. The organic phase was collected and the aqueous phase was extracted twice with EtOAc. The combined organic layers were washed with saturated aqueous NaHCO3 and brine, dried (MgSO4), filtered and concentrated. The residual oil was purified by flash chromatography (SiO2, eluent:gradient 25% to 50% EtOAc/hexane) to provide 1-(tert-butyldimethylsilyl)-4(R)-(hydroxymethyl)azetidin-2-one (8.46 g, 60% yield) as a white solid. 1H-NMR (400 MHz, CDCl3) δ3.74-3.69 (m, 1H), 3.65-3.56 (m, 2H), 3.1-2.98 (m, 1H), 2.81-2.76 (m, 1H), 2.01 (s, 1H), 0.89 (s, 9H), 0.18 (s, 3H), 0.16 (s, 3H). FAB MS m/z 216.2 (MH+).

Aufarbeitung

  1. additionwas added portionwise
  2. customquenched with aqueous HCl solution (10%) to pH 5-6
  3. customThe organic phase was collected
  4. extractionthe aqueous phase was extracted twice with EtOAc
  5. washThe combined organic layers were washed with saturated aqueous NaHCO3 and brine
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe residual oil was purified by flash chromatography (SiO2, eluent:gradient 25% to 50% EtOAc/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-3bb3168327344b0aa86dd8041e8726d3
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242439B1

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