Water → 8-Methylcoumarin

HRID 1099362

Reaktionsgleichung

Reaktionsgleichung von HRID 1099362
[OH:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11]([O-])(=[O:13])[CH3:12].[Na+].C(OC(=O)C)(=O)C.O>CCCCCC>[CH3:10][C:9]1[CH:8]=[CH:7][CH:6]=[C:3]2[C:2]=1[O:1][C:11](=[O:13])[CH:12]=[CH:4]2

Komponenten

6

Edukt 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 5227773-Methylsalicylaldehyde

Produkt 1

HCID 157348-MethylcoumarinAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Reaktionsbedingungen

Temperatur
177.5 °C

Versuchsvorschrift

The suspension of 2-Hydroxy-3-methyl benzaldehyde (30 gm, 0.220 mole) and anhydrous Sodium acetate (45 gm, 0.55 mole) in Acetic anhydride (45 gm, 0.44 mole) was heated at 175-180° C. for 6 hours. The reaction mixture was cooled; water (150 ml) and Hexane (60 ml) were added. It was stirred for an hour and filtered. The obtained solid was stirred with Diethyl ether (30 ml). Finally the suspension was filtered and dried to give 19 gm desired product.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. stirringThe obtained solid was stirred with Diethyl ether (30 ml)
  4. filtrationFinally the suspension was filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d2f367b4660d452b9b4537e0f3e82b7a
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143424B2

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