Water → 4-Ethyl-2-isopropoxy-benzonitrile

Temperatur

90 °C

4-Ethyl-1-iodo-2-isopropoxy-benzene (0.93 g, 3.2 mmol) was dissolved in dimethylformamide (5 mL). Zinc cyanide (226 mg, 1.92 mmol) was added. Argon gas was passed through the mixture for 10 min. Tetrakis(triphenylphosphine)-palladium(184 mg, 0.16 mmol) was added and the mixture was heated at 90° C. for 5 h. The reaction mixture was cooled to room temperature and poured into water. The mixture was extracted with diethyl ether. The organic extracts were washed with brine and dried over anhydrous magnesium sulfate. The solid was then filtered off, and the filtrate was concentrated in vacuo. Purification of the residue by flash chromatography (Biotage system, KP-Sil™ 32-63 μm, 60 Å silica gel) eluting with 10% diethyl ether in hexanes yielded 4-ethyl-2-isopropoxy-benzonitrile (0.34 g, 56%).

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionThe mixture was extracted with diethyl ether
3. washThe organic extracts were washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationThe solid was then filtered off
6. concentrationthe filtrate was concentrated in vacuo
7. customPurification of the residue by flash chromatography (Biotage system, KP-Sil™ 32-63 μm, 60 Å silica gel)
8. washeluting with 10% diethyl ether in hexanes

ORD-Eintrag

ord-cdd3bb24cb5f418f94d1f9c01ceb1f52

Quelldatensatz

uspto-grants-2003_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06617346B1