Methane → 4-Ethyl-4-phenyl-2-(2-phenylquinolin-4-yl)-imidazoline

HRID 1168457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1168457
[C:1]1([C:7]([NH2:12])([CH2:10][CH3:11])[CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Al](C)C.C.CO[C:20]([C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[N:25]=[C:24]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:23]=1)=O>C1(C)C=CC=CC=1.CO.C(Cl)Cl.O>[CH2:10]([C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][NH:9][C:20]([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]=[C:24]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:23]=2)=[N:12]1)[CH3:11]

Komponenten

9

Edukt 4

HCID 297MethaneHCID 211492-Phenylbutane-1,2-diamineHCID 609693Methyl 2-phenyl-4-quinolinecarboxylateHCID 16682925Trimethylaluminum

Produkt 1

HCID 1784352444-Ethyl-4-phenyl-2-(2-phenylquinolin-4-yl)-imidazoline

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel3×HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-Phenylbutane-1,2-diamine (328 mg, 2.0 mmol) in 4.4 mL of toluene is added dropwise to a stirred solution of trimethylaluminum (2.0 M, 1 mL) in 5 mL of toluene at below 10° C. under nitrogen. At the end of methane evolution, methyl-2-phenyl-4-quinolinecarboxylate (263 mg, 1 mmol) in 2 mL of toluene is gradually added at room temperature. The reaction mixture is refluxed for 3 hours under nitrogen. After cooling, the solution is treated with 1 mL of water, diluted with 1 mL of methanol and 1 mL of methylene chloride, and refluxed for 15 minutes. After separation of organic solvent and solvent evaporation, the residue is purified over silica gel chromatography eluting with 5-10% MeOH/CH2Cl2. The corresponding compound is obtained as a white solid.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 3 hours under nitrogen
  2. temperatureAfter cooling
  3. temperaturerefluxed for 15 minutes
  4. customAfter separation of organic solvent and solvent evaporation
  5. customthe residue is purified over silica gel chromatography
  6. washeluting with 5-10% MeOH/CH2Cl2
  7. customThe corresponding compound is obtained as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-8ef2641f27c3456aa287212e14769d17
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06624175B2

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