Water → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide

HRID 1188519

Reaktionsgleichung

Reaktionsgleichung von HRID 1188519
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br.O>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[Cl:1]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 81969N-(3-chloro-2-methylphenyl)acetamide

Produkt 1

HCID 86376N-(4-Bromo-3-chloro-2-methylphenyl)acetamideAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

A suspension of N-(3-chloro-2-methylphenyl)acetamide (11.12 g, 60.63 mmol) in acetic acid (80 mL) was cooled to ca. 10° C. and then treated with bromine (9.28 mL, 181.11 mmol). The resulting mixture was stirred at rt for 2 h. The cooled solution was then poured into water (100 mL). The resulting solid was collected via filtration and rinsed with water. Thorough drying afforded 15.83 g of a pale yellow solid: MS (APCI) m/z 264 (M+2 isotope).

Aufarbeitung

  1. filtrationThe resulting solid was collected via filtration
  2. washrinsed with water
  3. customThorough drying

Quellen und Nachweise

ORD-Eintrag
ord-f1133743ea624b9d97929e271ab0bdf6
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673948B2

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