Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid

HRID 1199075

Reaktionsgleichung

Reaktionsgleichung von HRID 1199075
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[I:13]Cl.O>C(O)(=O)C.II>[I:13][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[CH2:9][C:10]([OH:12])=[O:11]

Komponenten

6

Edukt 3

HCID 962WaterHCID 15719(3-Methoxyphenyl)acetic acidHCID 24640Iodine chloride

Produkt 1

HCID 8200712-(2-Iodo-5-methoxyphenyl)acetic acidAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 807IodineKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

Aufarbeitung

  1. customthe solid collected
  2. customIt was recrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-577c39de1e3b494d871a067200fb5e1c
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04898889

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