1,2-Dichloroethane → HCID 18616028, Verbindung

HRID 1263412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1263412
[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[C:8]([CH3:15])[C:6]=2[N:7]=1.[CH3:16][N:17]1[C:21](O)=[CH:20][CH:19]=[N:18]1.C(#N)C.C(Cl)CCl>CN(C1C=CN=CC=1)C.O.C(N(CC)CC)C>[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([C:12]([O:14][C:21]3[N:17]([CH3:16])[N:18]=[CH:19][CH:20]=3)=[O:13])=[C:8]([CH3:15])[C:6]=2[N:7]=1

Komponenten

8

Edukt 4

HCID 111,2-DichloroethaneHCID 6342AcetonitrileHCID 186160494-Methyl-2-(methylamino)-1,3-benzothiazole-5-carboxylic acidHCID 178481816HCID 178481816, Verbindung

Produkt 1

HCID 18616028HCID 18616028, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 962WaterLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

3.1 g of 2-methylamino-4-methylbenzothiazole-5-carboxylic acid (0.014 mol) and 1.4 g of 1-methyl-5-hydroxypyrazole (0.015 mol) were dissolved in 110 ml of abs. acetonitrile and admixed with 2.67 g of EDC (0.014 mol), 1,2 ml of triethylamine and a catalytic amount of DMAP. After the reaction had ended, the solution was poured into water and the mixture was extracted with ethyl acetate. The organic phase was washed and dried, and the product was then purified by crystallization. Yield: 2.2 g (52%).

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic phase was washed
  3. customdried
  4. customthe product was then purified by crystallization

Quellen und Nachweise

ORD-Eintrag
ord-293ef6d524064eb3bf4c40e69bbc5979
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06541423B1

Notizen zur Reaktion

Wird geladen…