Water → HCID 18394418, Verbindung

HRID 1268641Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1268641
[NH2:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4].[C:12](OC(=O)C)(=[O:14])C.O>C(O)=O>[CH:12]([NH:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4])=[O:14]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 7111750D-2-Thienylalanine

Produkt 1

HCID 18394418HCID 18394418, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

(2R)-2-Amino-3-(2-thienyl)propionic acid (5.00 g, 29.2 mmol) was dissolved in formic acid (50 ml). The solution was cooled to 0° C. Acetic acid anhydride (20 ml) was added dropwise. The reaction mixture was stirred for 16 h, while it was warming up to room temperature. It was cooled to 0° C. Water (20 ml) was added dropwise. The solution was warmed to room temperature. The solvent was removed in vacuo. The resiude was suspended in ethyl acetate (20 ml). The precipitation was filtered off, collected, and dried in vacuo, to give 3.60 g of crude (2R)-2-(formylamino)-3-(2-thienyl)propionic acid, which was used for the following step.

Aufarbeitung

  1. temperaturewas warming up to room temperature
  2. temperatureIt was cooled to 0° C
  3. temperatureThe solution was warmed to room temperature
  4. customThe solvent was removed in vacuo
  5. customThe precipitation
  6. filtrationwas filtered off
  7. customcollected
  8. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8257c9e98df544898e8d2b6cbd12c30d
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06555570B2

Notizen zur Reaktion

Wird geladen…