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Acetic Acid → 8-Ethyl-7,8-dihydro-5-hydroxy-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 127368
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 127368
C(O[C:4]([C:6]1[C:7]([NH:18][CH2:19][CH3:20])=[N:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:10][CH:11]=1)=[O:5])C.C([CH:23]([C:27](Cl)=[O:28])[C:24](Cl)=[O:25])C.[Na].[C:31](O)(=[O:33])[CH3:32]>C(OCC)C.C(O)C.O>[CH2:31]([O:33][C:27]([C:23]1[C:24](=[O:25])[N:18]([CH2:19][CH3:20])[C:7]2[N:8]=[C:9]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:10]=[CH:11][C:6]=2[C:4]=1[OH:5])=[O:28])[CH3:32]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

8

Edukt 4

HCID 176Acetic AcidHCID 5360545SodiumHCID 109209242-Ethylpropanedioyl dichlorideHCID 127840724-Ethylamino-2-phenyl-5-pyrimidine-carboxylic acid ethyl ester

Produkt 1

HCID 547318648-Ethyl-7,8-dihydro-5-hydroxy-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 702
Ethanol
Lösungsmittel
HCID 962WaterLösungsmittel
HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To 9.2 g. (0.034 mole) of 4-ethylamino-2-phenyl-5-pyrimidine-carboxylic acid ethyl ester in diethyl ether was added to 2.6 g. (0.017 mole) of ethyl malonyl chloride and then stirred 3 hours at room temperature. The reaction was then filtered and the filtrate stripped to dryness. This residue was dissolved in ethanol and added to a solution of 0.78 g. of sodium (0.034 mole) in ethanol and stirred at room temperature for 10 minutes. Acidification with acetic acid followed by the slow addition of water resulted in the formation of a precipitate. The crude product was removed by filtration and recrystallized from hexane m.p. 175°-177° C.--to give 1.0 g. of the title product.

Aufarbeitung

  1. filtrationThe reaction was then filtered
  2. dissolutionThis residue was dissolved in ethanol
  3. additionadded to a solution of 0.78 g
  4. customresulted in the formation of a precipitate
  5. customThe crude product was removed by filtration
  6. customrecrystallized from hexane m.p. 175°-177° C.
  7. customto give 1.0 g

Quellen und Nachweise

ORD-Eintrag
ord-7a839cecf3a847daa7fceadecd52a48a
Quelldatensatz
uspto-grants-1981_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04255568

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