Carbon Dioxide → 4-(Decyloxy)-3-fluorobenzoic acid

HRID 1289339Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289339
C([Li])CCC.Br[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:9]([F:24])[CH:8]=1.[C:25](=[O:27])=[O:26].Cl>C1COCC1.CCOCC>[CH2:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([C:25]([OH:27])=[O:26])=[CH:8][C:9]=1[F:24])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

Komponenten

7

Edukt 4

HCID 280Carbon DioxideHCID 313Hydrochloric AcidHCID 146925094-Decyloxy-3-fluorophenyl bromideHCID 178418339Butyllithium

Produkt 1

HCID 6399744-(Decyloxy)-3-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of n-butyllithium was added dropwise to a stirred, cooled (-78° C.) solution of compound of step 2.1 in dry THF. The mixture was maintained under these conditions for 40 mins and then poured into a slurry of dry ether and cardice. The solution was acidified with 36% HCl, washed with water and dried (magnesium sulphate). The solvent was removed to yield a white solid.

Aufarbeitung

  1. temperatureThe mixture was maintained under these conditions for 40 mins
  2. washwashed with water
  3. dry with materialdried (magnesium sulphate)
  4. customThe solvent was removed
  5. customto yield a white solid

Quellen und Nachweise

ORD-Eintrag
ord-1090e088da22497eb8bcb2419e46c059
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750050

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