Acetic Acid → N-Acetyl-L-proline

HRID 1292328

Reaktionsgleichung

Reaktionsgleichung von HRID 1292328
[S-][C:2]#[N:3].[NH4+].[C:5]([OH:8])(=[O:7])[CH3:6].F[C:10](F)(F)[C:11]([OH:13])=O.[C:16](OC(=O)C)(=O)[CH3:17]>C(N(CC)CC)C>[C:11]([N:3]1[CH2:2][CH2:17][CH2:16][C@H:6]1[C:5]([OH:8])=[O:7])(=[O:13])[CH3:10]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 6422Trifluoroacetic acidHCID 7918Acetic AnhydrideHCID 15666Ammonium thiocyanate

Produkt 1

HCID 66141N-Acetyl-L-proline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

ammonium thiocyanate (BDH, Analar), Aristar acetic acid (BDH), eptide synthesis grades of trifluoroacetic acid and acetic anhydride (Applied Biosystems) were used without further purification. Reagents for amino acid analysis of phenylthiocarbamyl amino acids were all of the highest possible purity (Inglis et al Biochem. Biophys. Methods 15:249, 1988). Pierce 6M constant boiling HC1 and Analar phenol (BDH) were used for hydrolysis and N,N-diisopropylethylamine (DIEA, Peptide Synthesis Grade, Applied Biosystems) replaced triethylamine in the drying reagent and in the coupling buffer.

Aufarbeitung

  1. customwere used without further purification
  2. customand Analar phenol (BDH) were used for hydrolysis and N,N-diisopropylethylamine (DIEA, Peptide Synthesis Grade, Applied Biosystems)

Quellen und Nachweise

ORD-Eintrag
ord-34e412f94b714d90839c31b45566e546
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05756667

Verknüpfte Notizen

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