Water → HCID 86744882, Verbindung

HRID 129315

Reaktionsgleichung

Reaktionsgleichung von HRID 129315
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][C:8]([CH2:13][CH2:14][CH3:15])([CH2:11][OH:12])[CH2:9][OH:10].[OH2:16]>N1C=CC=CC=1.C(OCC)C>[CH3:1][S:2]([OH:4])(=[O:6])=[O:3].[CH3:1][S:2]([OH:4])(=[O:16])=[O:3].[CH3:1][S:2]([OH:4])(=[O:6])=[O:3].[OH:6][CH2:7][C:8]([CH2:13][CH2:14][CH3:15])([CH2:11][OH:12])[CH2:9][OH:10]

Komponenten

6

Edukt 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 81928Butylidynetrimethanol

Produkt 1

HCID 86744882HCID 86744882, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Methanesulphonyl chloride (74.0 g) was added dropwise over 30 minutes to a solution of 2-hydroxymethyl-2-n-propylpropan-1,3-diol (28.0 g) in dry pyridine (200 ml) under nitrogen at 0° C. The mixture was allowed to warm to room temperature. After stirring for 18 hours the mixture was poured into water (200 ml) and extracted with chloroform (2×200 ml). The chloroform extracts were washed with water (2×100 ml), dried over anhydrous magnesium sulphate and evaporated in vacuo to give a brown solid. This was stirred in dry diethyl ether (200 ml) to give 2-hydroxymethyl-2-n-propylpropan-1,3-diol trimethanesulphonate as a white solid. (70.0 g)(m.pt.103.6°).

Aufarbeitung

  1. extractionextracted with chloroform (2×200 ml)
  2. washThe chloroform extracts were washed with water (2×100 ml)
  3. dry with materialdried over anhydrous magnesium sulphate
  4. customevaporated in vacuo
  5. customto give a brown solid

Quellen und Nachweise

ORD-Eintrag
ord-e63dbdcee095420d97b4d4030ddcaad7
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05466710

Verknüpfte Notizen

Wird geladen…