Sodium Chloride → 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol

HRID 1295718

Reaktionsgleichung

Reaktionsgleichung von HRID 1295718
[CH2:1]([OH:6])[CH2:2][CH2:3][CH2:4][OH:5].CC([O-])(C)C.[K+].[F:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:15]=1F.[Cl-].[Na+]>O.C1(C)C=CC=CC=1.CS(C)=O>[F:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:15]=1[O:5][CH2:4][CH2:3][CH2:2][CH2:1][OH:6]

Komponenten

8

Edukt 4

HCID 5234Sodium ChlorideHCID 80641,4-ButanediolHCID 94741,2,4,5-TetrafluorobenzeneHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 693646634-(2,4,5-Trifluoro-phenoxy)butan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a mixture of 1,4-butanediol (15 g, 0.17 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mmol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo giving the title compound. This material was used directly in the next step.

Aufarbeitung

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-663d6016ba36490f8673a3c4952bbb51
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07244722B2

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