Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

HRID 130285

Reaktionsgleichung

Reaktionsgleichung von HRID 130285
[Cl:1][P:2](Cl)[O:3][CH2:4][CH2:5][C:6]#[N:7].[CH:9]([N:12]([CH:15]([CH3:17])[CH3:16])CC)([CH3:11])[CH3:10].C(NC(C)C)(C)C>ClCCl.CN(C1C=CN=CC=1)C>[CH:9]([N:12]([P:2]([Cl:1])[O:3][CH2:4][CH2:5][C:6]#[N:7])[CH:15]([CH3:17])[CH3:16])([CH3:11])[CH3:10]

Komponenten

6

Edukt 3

HCID 7912DiisopropylamineHCID 81531DiisopropylethylamineHCID 195897beta-Cyanoethyl phosphorodichloridite

Produkt 1

HCID 27348442-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 0.54 mL(4.0 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 0.64 mL (4.0 mmol) of diisopropylamine under Argon. The reaction mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for the next step reaction.

Aufarbeitung

  1. customthe reaction mixture is ready for the next step reaction

Quellen und Nachweise

ORD-Eintrag
ord-1f09ddb2ebd64198839d633289cfe614
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07381533B2

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