Water → n-(2-Fluoro-4-hydroxyphenyl)acetamide

HRID 133732

Reaktionsgleichung

Reaktionsgleichung von HRID 133732
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[F:16].O>C(O)(=O)C>[F:16][C:10]1[CH:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=1[NH:8][C:5](=[O:7])[CH3:6]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 27359194-Amino-3-fluorophenol

Produkt 1

HCID 190616n-(2-Fluoro-4-hydroxyphenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Acetic anhydride (1.3 ml, 13.8 mmol) was added dropwise to a solution of 4-amino-3-fluorophenol (1.0 g, 7.9 mmol) in acetic acid (25 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 h and water (2 ml) was added and the stirring was continued for 30 minutes at room temperature. The mixture was evaporated to dryness in vacuo. The yield of the crude product was 1.3 g (100%) and it was used without further purification.

Aufarbeitung

  1. waitthe stirring was continued for 30 minutes at room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-87286c2ade0143448a517e8f0fd7426b
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390923B2

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