Acetone → [2-(4-Fluorophenyl)ethyl](propan-2-yl)amine

HRID 1351257

Reaktionsgleichung

Reaktionsgleichung von HRID 1351257
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:14])=O.CO.C([BH3-])#N.[Na+]>C(O)(=O)C.C(OCC)(=O)C.O>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH:12]([CH3:14])[CH3:11])=[CH:4][CH:3]=1

Komponenten

8

Edukt 4

HCID 180AcetoneHCID 887MethanolHCID 4653p-FluorophenethylamineHCID 5003444Sodium cyanoborohydride

Produkt 1

HCID 21098562[2-(4-Fluorophenyl)ethyl](propan-2-yl)amine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4-fluorophenethylamine (1.4 g) in acetic acid (10 mL) was added dropwise acetone (0.82 mL) and methanol (20 mL). After sodium cyano-borohydride (0.64 g) was added, and the solution was stirred at room temperature for 2.5 hours. After adding water and diluting with ethyl acetate, the solution was washed with water and saturated sodium chloride water. After drying with anhydrous sodium sulfate, the residue that was obtained upon removing the solvent by evaporation was purified by NAM silica gel column chromatography (hexane/ethyl acetate), and the title compound (0.62 g) was obtained as colorless solids.

Aufarbeitung

  1. washthe solution was washed with water and saturated sodium chloride water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe residue that was obtained
  4. customupon removing the solvent
  5. customby evaporation
  6. customwas purified by NAM silica gel column chromatography (hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-7b3d68e78fb04411aa64ef3012cb2c39
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07217723B2

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