Bicyclo[4.2.0]octan-7-one, 8,8-dichloro- → Bicyclo(4.2.0)octan-7-one
Reaktionsgleichung
Cl[C:2]1(Cl)[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[C:3]1=[O:10]>C(O)(=O)C.C(OCC)C.[Zn]>[CH:9]12[CH2:2][C:3](=[O:10])[CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8]2Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
(1RS,6SR)-8,8-dichlorobicyclo[4.2.0]octan-7-one (preparation 18) (8.60 g, 44.6 mmol) was heated to reflux in acetic acid (100 ml) with zinc dust (29.0 g, 446 mmol). After 4 hrs the mixture was cooled to room temperature, diluted with diethyl ether (200 ml) and washed with 2N NaOH (2×100 ml) and then with saturated aqueous NaHCO3 (4×100 ml). The ether phase was collected, dried (MgSO4) and the solvent was removed under reduced pressure to give 4.79 g of the title compound as a clear oil.
Aufarbeitung
- washwashed with 2N NaOH (2×100 ml)
- customThe ether phase was collected
- dry with materialdried (MgSO4)
- customthe solvent was removed under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-c99af70be8324715b61b4ab26568adf6
- Quelldatensatz
- uspto-grants-2003_07
- Patentnummer
- US06596900B2
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