Potassium Bromide → tert-butyl (3R)-3-formylpyrrolidine-1-carboxylate

Temperatur

5 °C

To a solution of (R)-Boc-3-pyrrolidinemethanol (5.0 g, 24.8 mmol) in DCM was added TEMPO (80 mg, 0.5 mmol) and potassium bromide (150 mg, 1.3 mmol). This mixture was cooled to 5° C. and vigorously stirred as a pre-chilled (at 0° C.) 1:1 mixture of NaOCl in water (53 mL) and a saturated, aqueous NaHCO3 solution (53 mL) was added dropwise. The resultant mixture was extracted with DCM (3×50 mL). The combined organic layers were washed with water (50 mL) and saturated aqueous NaCl (50 mL). The organic layer was dried over anhydrous Na2SO4 to yield 4.3 g of the title compound, which was used without further purification.

1. temperaturea pre-chilled
2. extractionThe resultant mixture was extracted with DCM (3×50 mL)
3. washThe combined organic layers were washed with water (50 mL) and saturated aqueous NaCl (50 mL)
4. dry with materialThe organic layer was dried over anhydrous Na2SO4

ORD-Eintrag

ord-0c9c69f2b97d448091afe09b599d8c7b

Quelldatensatz

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07888386B2