Cyanogen Bromide → HCID 178508200, Verbindung

HRID 1368001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1368001
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH2:11])[CH:5]=1)([O-:3])=[O:2].Br[C:13]#[N:14]>C(O)C.O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]2[NH:10][C:13]([NH2:14])=[N:11][C:6]=2[CH:5]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 2

HCID 10476Cyanogen BromideHCID 51117914-Nitro-1,2-phenylenediamine

Produkt 1

HCID 178508200HCID 178508200, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

7.6 g (50 mmol) of 4-nitro-ortho-phenylenediamine was dissolved were dissolved in 100 mL of ethanol and 20 mL of H2O. 7.9 g (75 mmol) of BrCN was added in one portion to this stirring solution, and the resulting mixture was heated under reflux for 1.0 h. The reaction mixture was cooled to room temperature, concentrated to 20 mL then neutralized with saturated NaHCO3 solution to pH 8, and resulting solid 5-nitro-1H-benzoimidazol-2-ylamine collected via filtration was used directly in the next step without further purification.

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 1.0 h
  3. concentrationconcentrated to 20 mL

Quellen und Nachweise

ORD-Eintrag
ord-a54b3feb1e4b424bb907d2db8507796c
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07893267B2

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