Uracil → Ethyl 2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate
Reaktionsgleichung
[NH:1]1[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>O.CS(C)=O>[O:3]=[C:2]1[NH:4][C:5](=[O:6])[CH:7]=[CH:8][N:1]1[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]Komponenten
7
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
A dimethyl sulfoxide solution (150 mL) containing 10.02 g of uracil, 3.3 mL of ethyl bromoacetate, 13.85 g of potassium carbonate and 4.52 g of sodium iodide was stirred at 90° C. for six hours. The reaction mixture was poured over water and the mixture was extracted with chloroform. The extracts were combined, dried over sodium sulfate and concentrated in vacuo. The concentrate was poured over a saturated saline solution, the mixture was extracted with ethyl acetate and the extract was dried over sodium sulfate. After concentration, the resulting residue was recrystallized from ethyl acetate to give 2.30 g of ethyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-acetate.
Aufarbeitung
- extractionthe mixture was extracted with chloroform
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
- additionThe concentrate was poured over a saturated saline solution
- extractionthe mixture was extracted with ethyl acetate
- dry with materialthe extract was dried over sodium sulfate
- concentrationAfter concentration
- customthe resulting residue was recrystallized from ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-c94bbe17386441bf9047c526e886e22b
- Quelldatensatz
- uspto-grants-1999_06
- Patentnummer
- US05912261
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