Water → Prasugrel

Temperatur

0 °C

2-(Tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (1.0 eq.) prepared by example 4 was dissolved in acetone (10.0 mL) and the mixture was cooled to 0° C. Triethylamine (1.1 eq.) was added slowly followed by adding 4-dimethylaminopyridine (DMAP) (0.025 g) and the mixture was stirred for 10 minutes. Acetic anhydride (1.5 eq.) in acetone was then added. The reaction was monitored by Thin Layer Chromatography (TLC) (petroleum ether/ethyl acetate=10/1 or 5/1). After the reaction was completed, cold water (7.5 mL) was added to the reaction mixture and the mixture was stirred for 15 minutes. It was then cooled to −5° C. and further stirred for 3 hours. After filtration, solid precipitate was washed with a mixture of pre-cooled acetone/water (1:1 v/v) (10 ml). The obtained prasugrel free base was dried under vacuum at 50° C. for 24 hours. The yield was 90%.

1. stirringthe mixture was stirred for 15 minutes
2. temperatureIt was then cooled to −5° C.
3. stirringfurther stirred for 3 hours
4. filtrationAfter filtration, solid precipitate
5. washwas washed with a mixture of pre-cooled acetone/water (1:1 v/v) (10 ml)
6. dry with materialThe obtained prasugrel free base was dried under vacuum at 50° C. for 24 hours

ORD-Eintrag

ord-a7749db02de248ecb5c58fbef01f6e7b

Quelldatensatz

uspto-grants-2015_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08937053B2