Formaldehyde → HCID 54232589, Verbindung

HRID 1446834Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1446834
N[C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([NH2:19])=[O:18].[CH2:20]=O.[C:22]([BH3-])#[N:23].[Na+].[OH-].[Na+]>C(#N)C.C(O)(=O)C>[C:8]([C:7]1[C:2]([N:23]([CH3:22])[CH3:20])=[C:3]([CH2:16][C:17]([NH2:19])=[O:18])[CH:4]=[CH:5][CH:6]=1)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

7

Edukt 4

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 151075NepafenacHCID 5003444Sodium cyanoborohydride

Produkt 1

HCID 54232589HCID 54232589, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 12.7 g (0.05 mol) of 2-amino-3-benzoyl-phenylacetamide in 150 ml of acetonitrile is treated four times with 16 ml (0.2 mole) of 37% formalin, 6.4 g (0.1 mole) of sodium cyanoborohydride and 2 ml of glacial acetic acid with a 15 minute stirring period between each treatment. The mixture is finally poured into dilute sodium hydroxide and extracted three times with diethylether. The ether extracts are combined, dried over magnesium sulfate and concentrated. The product is isolated by column chromatography.

Aufarbeitung

  1. extractionextracted three times with diethylether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe product is isolated by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c16df1c2c8d04b8da75839f95b0e666d
Quelldatensatz
uspto-grants-1982_02
Patentnummer
US04313949

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