1,5,6,7-Tetrahydro-4H-indol-4-one → 1,5,6,7-Tetrahydro-indol-4-one oxime

HRID 1452031

Reaktionsgleichung

Reaktionsgleichung von HRID 1452031
C([O-])(=O)C.[Na+].Cl.[NH2:7][OH:8].O=[C:10]1[CH2:18][CH2:17][CH2:16][C:15]2[NH:14][CH:13]=[CH:12][C:11]1=2>O.C(O)C>[N:7](=[C:10]1[CH2:18][CH2:17][CH2:16][C:15]2[NH:14][CH:13]=[CH:12][C:11]1=2)[OH:8]

Komponenten

6

Edukt 3

HCID 2802291,5,6,7-Tetrahydro-4H-indol-4-oneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Produkt 1

HCID 9156771,5,6,7-Tetrahydro-indol-4-one oxime

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 6.08 g of sodium acetate, 5.15 g of hydroxylamine hydrochloride, and 5.25 g of 4-keto-4,5,6,7-tetrahydro indole in 12 mL of water and 36 mL of ethanol was heated at 50° C. for 3 hr, quenched in water, extracted with ethyl acetate and dried over magnesium sulfate. The solvents were removed in vacuo to give a mixture of oxime isomers which was characterized by NMR and Mass spectroscopy.

Aufarbeitung

  1. customquenched in water
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. customThe solvents were removed in vacuo
  5. customto give

Quellen und Nachweise

ORD-Eintrag
ord-67f58450e7b44dd5893acb47d5bfeea7
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05606054

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