Sulfuric Acid → Ethyl 3-amino-6-bromopicolinate

HRID 1478541

Reaktionsgleichung

Reaktionsgleichung von HRID 1478541
[NH2:1][C:2]1[C:3]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[Br:18]Br>O.CC(O)=O>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:4][C:5]([Br:18])=[CH:6][CH:7]=1

Komponenten

6

Edukt 3

HCID 1118Sulfuric AcidHCID 24408Bromine2×HCID 565054Ethyl 3-aminopyridine-2-carboxylate

Produkt 1

HCID 25137688Ethyl 3-amino-6-bromopicolinate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

To a suspension of ethyl 3-aminopyridine-2-carboxylate (39.96 g, 241 mmol) in water (330 ml) was added H2SO4 (8 ml) and AcOH (16 ml). To this solution was added a solution of bromine in AcOH (84 ml) at ambient temperature under vigorous stirring so that the internal temperature remained around 25° C. After all bromine was added, stirring was continued for 1.5 h then the orange suspension was filtered giving ethyl 3-amino-6-bromo-pyridine-2-carboxylate.

Aufarbeitung

  1. customremained around 25° C
  2. stirringstirring
  3. filtrationthe orange suspension was filtered

Quellen und Nachweise

ORD-Eintrag
ord-be8199ea10ce466cab30937a4e63268c
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09403845B2

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