Acetic Acid → 3-Amino-6-chloropyridine-2-carbonitrile

HRID 1517427Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517427
[Cl:1][C:2]1[N:7]=[C:6]([C:8]#[N:9])[C:5]([N+:10]([O-])=O)=[CH:4][CH:3]=1.C(O)(=O)C.[O-]S(S([O-])=O)=O.[Na+].[Na+].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O>[NH2:10][C:5]1[C:6]([C:8]#[N:9])=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 14812Phosphorus oxide (P4O10)HCID 24489Sodium DithioniteHCID 133817056-Chloro-3-nitropyridine-2-carbonitrile

Produkt 1

HCID 5927503-Amino-6-chloropyridine-2-carbonitrileAusbeute 80,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a suspension of 6-chloro-3-nitro-pyridine-2-carbonitrile (5.5 g, 30 mmol) in water (100 ml), was added acetic acid (5.4 ml, 90 mmol). The mixture was stirred at room temperature for 20 minutes. Then, Na2S2O4 (20 g, 86%, 90 mmol) was added slowly. The reaction mixture was stirred at room temperature for another 2 hours. The precipitate was filtered off and washed with cold water (2×10 ml). The precipitate was dried over P2O5 yielding the title compound as a yellowish solid (3.7 g, yield: 80%) which was characterised as follows:

Aufarbeitung

  1. stirringThe reaction mixture was stirred at room temperature for another 2 hours
  2. filtrationThe precipitate was filtered off
  3. washwashed with cold water (2×10 ml)

Quellen und Nachweise

ORD-Eintrag
ord-35e062a7687e45758a82e9a06f4508d2
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232278B2

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