Bromine → HCID 67374784, Verbindung

HRID 1517549Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517549
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]([OH:8])=[O:7].CC([O-])=O.[Na+].[Br:21]Br>CC(O)=O>[Br:21][C:9]1[C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]([O:2][CH3:1])=[C:11]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:10]=1

Komponenten

5

Edukt 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 127397584-tert-Butyl-3-methoxybenzoic acid

Produkt 1

HCID 67374784HCID 67374784, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

step 1—To a solution of 3-methoxy-4-tert-butylbenzoic acid (1.0 eq, 48.02 mmol, 10.00 g and NaOAc (2.0 eq, 96.03 mmol, 7.88 g) in HOAc (75 mL) at RT was added dropwise Br2 (2.0 eq, 96.03 mmol, 4.94 mL). The resulting mixture was heated at 50° C. for 24 h, cooled to RT and poured into a mixture of ice-water. The slightly orange-colored solid was collected by suction filtration, washed with water, dried in the oven at 40° C. to afford 12.87 g of 6-bromo-4-tert-butyl-3-methoxybenzoic acid the product (118).

Aufarbeitung

  1. temperaturecooled to RT
  2. filtrationThe slightly orange-colored solid was collected by suction filtration
  3. washwashed with water
  4. customdried in the oven at 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-b87c6be46afa4d1b82056429a0d9c82e
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232271B2

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