Acetic Acid → 6-(2,4-Dichloro-benzenesulfonyl)-2H-pyridazin-3-one

HRID 1581490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1581490
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=1.C(OO)(=[O:19])C.C(O)(=O)C.[OH2:26]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9]([C:10]1[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=1)(=[O:19])=[O:26]

Komponenten

5

Edukt 4

HCID 176Acetic AcidHCID 962WaterHCID 6585Peracetic AcidHCID 225069506-(2,4-dichloro-phenylsulfanyl)-2H-pyridazin-3-one

Produkt 1

HCID 98361006-(2,4-Dichloro-benzenesulfonyl)-2H-pyridazin-3-oneAusbeute 37 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 6-(2,4-dichloro-phenylsulfanyl)-2H-pyridazin-3-one (418 mg), peracetic acid (3.2 mL) and acetic acid (3.2 mL) was prepared and stirred for 2.5 hours at 80° C. The reaction mixture was then cooled to room temperature and poured into water (50 mL). The resulting white solid was collected and dried to obtain the title product, 6-(2,4-dichloro-benzenesulfonyl)-2H-pyridazin-3-one, (37%, 173 mg); mp, 202-203° C.; NMR 7.15 (d, 1H), 7.81 (dd, 1H), 8.03 (m, 2H), 8.25 (d, 1H), 13.88 (s, 1H).

Aufarbeitung

  1. customwas prepared
  2. temperatureThe reaction mixture was then cooled to room temperature
  3. customThe resulting white solid was collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-31701cc4d37f43adb2cbbd5dcf7992cc
Quelldatensatz
uspto-grants-2004_05
Patentnummer
US06730674B2

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