Methane → 2H-Purine-2-thione, 6-amino-3,7-dihydro-

HRID 1585556Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585556
[NH:1]1[C:10](=S)[C:9]2[NH:8][CH:7]=[N:6][C:5]=2[NH:4][C:2]1=[S:3].C([NH2:14])C.C>O>[NH:1]1[C:10]([NH2:14])=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[N:4][C:2]1=[S:3]

Komponenten

5

Edukt 3

HCID 297MethaneHCID 6341EthylamineHCID 12682523,9-Dihydro-1H-purine-2,6-dithione

Produkt 1

HCID 15020112H-Purine-2-thione, 6-amino-3,7-dihydro-Ausbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

6.67 g (16 mmoles) of dithioxanthine and 52 ml of 70% ethylamine in water were heated to 150° C. in a pressure reactor (250 psi) for 12 hours under nitrogen. The solution was treated with charcoal (5%), filtered, and evaporated in vacuo to dryness. The residue was suspended in water, acidified with 1N HCl to pH 4 and neutralized to pH 8 with sodium bicarbonate. The solid was collected, washed and dried to give 6.66 g (97.4%) of crude thioisoguanine.

Aufarbeitung

  1. filtrationfiltered
  2. customevaporated in vacuo to dryness
  3. customThe solid was collected
  4. washwashed
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-311ee15bdf6a410cb232335936b748e8
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05939422

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