Formic Acid → 1-Pentanol

HRID 1591284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1591284
[CH:1](O)=[O:2].C(O[C:8](=[O:10])[CH3:9])(=O)C.[NH2:11][C:12]1[S:13][CH:14]=[C:15]([O:19][CH2:20][CH3:21])[C:16]=1[C:17]#[N:18]>O>[CH:1]([NH:11][C:12]1[S:13][CH:14]=[C:15]([O:19][CH2:20][CH3:21])[C:16]=1[C:17]#[N:18])=[O:2].[CH2:8]([OH:10])[CH2:9][CH2:14][CH2:15][CH3:16]

Komponenten

6

Edukt 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 137423802-Amino-4-ethoxythiophene-3-carbonitrile

Produkt 2

HCID 62761-PentanolHCID 13742382HCID 13742382, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

200 parts of formic acid are added dropwise to 500 parts of acetic anhydride at room temperature, and 168 parts of 2-amino-3-cyano-4-ethoxythiophene are introduced after 2 hours. The mixture is stirred for 4 hours at 50° C., after which 1000 parts of water are run into the hot mixture. The mixture is cooled and the product is then filtered off under suction, washed with water and dried. 174 parts of 2-formylamino-3-cyano-4-ethoxythiophene of melting point 191°-192° C. (from pentanol) are obtained.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. filtrationthe product is then filtered off under suction
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8a91f6767cb24a1ebf79699d8a5ea29b
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05206375

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