Methane → HCID 12650295, Verbindung

HRID 1605168Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1605168
Cl[C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].C>O.[Cu].CN(C)C=O>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:2]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:15][CH:14]=1

Komponenten

8

Edukt 4

HCID 297MethaneHCID 2879P-CresolHCID 57872,4-Dichlorobenzoic AcidHCID 11430Potassium Carbonate

Produkt 1

HCID 12650295HCID 12650295, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23978CopperKatalysatorHCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 15 g. of 2,4-dichlorobenzoic acid, 10 g. of p-methylphenol, 0.5 g. of copper powder and 20 g. of anhydrous potassium carbonate in 200 ml. of dimethylformamide is heated to 165° C and maintained thereat with stirring and under a nitrogen atmosphere. After monitoring via tlc indicates the reaction is substantially complete, the reaction mixture is diluted with water, treated with charcoal, filtered and the clear filtrate acidified. The precipitate is isolated by suction filtration, washed neutral and dried to give 2-(p-methylphenyloxy)-4-chlorobenzoic acid.

Aufarbeitung

  1. additionA mixture of 15 g
  2. temperaturemaintained
  3. filtrationfiltered
  4. customThe precipitate is isolated by suction filtration
  5. washwashed neutral
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ea08849779bf48ec85d709fd9f0fa43b
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03949084

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