Ammonium Chloride → 4-(3-Chloro-phenyl)-2-[5-methoxy-6-(3-morpholin-4-yl-propoxy)-benzoimidazol-1-yl]-thiazole 5-carboxylic acid amide

HRID 1667773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1667773
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([N:16]3[C:20]4[CH:21]=[C:22]([O:27][CH2:28][CH2:29]CO)[C:23]([O:25][CH3:26])=[CH:24][C:19]=4[N:18]=[CH:17]3)[S:11][C:12]=2[C:13]([NH2:15])=[O:14])[CH:5]=[CH:6][CH:7]=1.[CH2:32]([N:34]([CH:38]([CH3:40])C)[CH:35](C)C)[CH3:33].CS(Cl)(=O)=[O:43].[Cl-].[NH4+]>O.CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([N:16]3[C:20]4[CH:21]=[C:22]([O:27][CH2:28][CH2:29][CH2:35][N:34]5[CH2:38][CH2:40][O:43][CH2:33][CH2:32]5)[C:23]([O:25][CH3:26])=[CH:24][C:19]=4[N:18]=[CH:17]3)[S:11][C:12]=2[C:13]([NH2:15])=[O:14])[CH:5]=[CH:6][CH:7]=1

Komponenten

7

Edukt 4

HCID 25517Ammonium ChlorideHCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 674454694-(3-Chloro-phenyl)-2-[6-(3-hydroxy-propoxy)-5-methoxy-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Produkt 1

HCID 468323014-(3-Chloro-phenyl)-2-[5-methoxy-6-(3-morpholin-4-yl-propoxy)-benzoimidazol-1-yl]-thiazole 5-carboxylic acid amideAusbeute 26,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 0.070 g (0.15 mmole) of 4-(3-chloro-phenyl)-2-[6-(3-hydroxy-propoxy)-5-methoxy-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide (I.42a), 0.039 g (0.30 mmole) of ethyldiisopropylamine and 3 mL of dimethylformamide at 0 degrees was added 0.021 g (0.18 mmole) of methanesulfonyl chloride. Stirring was continued for 1 hour and then 1 mL of saturated ammonium chloride solution was added. The mixture was poured into 25 mL of water and extracted three times with 20 mL of ethyl acetate. The combined organic extracts were washed three times with 25 mL of water, once with 25 mL of saturated sodium bicarbonate solution, once with 25 mL of brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was heated at 80 degrees for 1 hour with 2 mL of dimethylformamide and 0.080 mL of morpholine. The cooled mixture was poured into 25 mL of water and extracted three times with 20 mL of ethyl acetate. The combined organic extracts were washed three times with 25 mL of water, once with 25 mL of saturated sodium bicarbonate solution, once with 25 mL of brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with methanol-dichloromethane (8:92) to give 0.021 g of 4-(3-chloro-phenyl)-2-[5-methoxy-6-(3-morpholin-4-yl-propoxy)-benzoimidazol-1-yl]-thiazole 5-carboxylic acid amide (I.43) as a pink solid. MH+/Z=528

Aufarbeitung

  1. extractionextracted three times with 20 mL of ethyl acetate
  2. washThe combined organic extracts were washed three times with 25 mL of water
  3. dry with materialonce with 25 mL of saturated sodium bicarbonate solution, once with 25 mL of brine, dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. temperatureThe residue was heated at 80 degrees for 1 hour with 2 mL of dimethylformamide and 0.080 mL of morpholine
  7. additionThe cooled mixture was poured into 25 mL of water
  8. extractionextracted three times with 20 mL of ethyl acetate
  9. washThe combined organic extracts were washed three times with 25 mL of water
  10. dry with materialonce with 25 mL of saturated sodium bicarbonate solution, once with 25 mL of brine, dried over anhydrous magnesium sulfate
  11. filtrationfiltered
  12. concentrationconcentrated under reduced pressure
  13. customThe residue was purified by silica gel chromatography
  14. washeluting with methanol-dichloromethane (8:92)

Quellen und Nachweise

ORD-Eintrag
ord-ce87012465774420891e695cbaccaf35
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044213B2

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