Water → HCID 178508959, Verbindung

HRID 1691835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1691835
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[Br:9]Br.O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[Br:9]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 1785076342-Amino-6-hydroxypyridine

Produkt 1

HCID 178508959HCID 178508959, VerbindungAusbeute 52,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 6-amino-pyridin-2-ol (5 g, 45.4 mmol) in glacial acetic acid (60 mL) was added bromine (2.33 mL, 45.4 mmol) under Ar atmosphere. The mixture was stirred for 20 minutes, then water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (Na2SO4), filtered and concentrated to dryness to obtain crude 6-amino-5-bromo-pyridin-2-ol (4.53 g).

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-5bf03174e1a1430cbfb9790ebf829c4b
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153809B2

Notizen zur Reaktion

Wird geladen…