Bromine → alpha-Bromo-3-chloropropiophenone

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:12]Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH:9]([Br:12])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Komponenten

Edukt 2

HCID 24408Bromine2×

HCID 5871283'-Chloropropiophenone

Produkt 1

HCID 4992116alpha-Bromo-3-chloropropiophenone

Versuchsvorschrift

To 1 mole of m-chloropropiophenone was heated to 70±5° C., bromine was added dropwise under stirring. The reaction temperature was kept at 70±5° C. during the addition of bromine and kept for 5.5 hours after the addition. m-chloro-α-bromopropiophenone (compound of formula (II)) was obtained.

Aufarbeitung

additionafter the addition

Quellen und Nachweise

ORD-Eintrag: ord-aaa3ab01a7134fa488f6490830c8d0af
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07737302B2

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